Customers who have configured a masquerade domain on a virtual SMTP server may experience problems sending outbound emails through the Proofpoint Essentials platform. Proofpoint Essentials does not support the use of masquerade domains - this is because emails may appear to be sent by mailboxes that are not registered on the platform and will be denied relay access.
Also see:
Can Proofpoint Essentials be used to forward email for non-registered domains?
554 5.7.1: Relay access denied
Sending to Distribution Groups with external domain recipients
Carlos Rios
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